Friday, June 22, 2012

The Body’s Protein Cleaning Machine





[the protein ubiquitin - the cleaning machine]

According to a recent article in the New York Times, proteins are the machines that carry out the directions of genes. They must be formed at a certain moment and destroyed when they are no longer needed, or when they go bad. 

A cell is something like an orchestra, with thousands of players. These are the proteins. They must all work together in harmony and play their parts at the right moment.

A cell knows when to eliminate a protein by using a tagging system. Every cell has within it a special protein that is everywhere: ubiquitin. Out of the thousands of proteins, this one tags damaged and bad proteins, binds to them and creates a molecular “kiss of death” until they are chopped up and degraded.

Parkinson’s disease and Alzheimer’s are caused by proteins accumulating in the brain and destroying brain cells. The reason we don’t get Alzheimer’s when we are 10 is that when we are young, the bad proteins are disposed of quickly. With age, the cell’s machinery may lose the ability to do that.

It's incredible to consider the vastly complex and perfectly orchestrated machinery which is functioning in each one of our 60 to 90 trillion cells.

How accurate the Jewish prayer said after elimination is: Blessed are You, Lord, Who heals all flesh and acts wondrously.

24 comments:

Ironmistress said...

This was a nice one.

I would like you to see writing about tobacco, smoking and addiction.

Anonymous said...

This article is so stupid! there is no documented proof before the time of Franklin Delano Roosevelt that proteins actually exist!

Abe said...

"How accurate the Jewish prayer said after elimination is: Blessed are You, Lord, Who heals all flesh and acts wondrously."

Except when the lord doesn't act wondrously and heal all flesh.
But who am I to impugn the lord's mercurial nature? Maybe our intellect is just too unrefined to appreciate the lord's unpredictable disposition.
My theory however, is the lord is still just a juvenile deity and we'll have too wait another 4 billion light years until he matures into the righteous, infallible god that heals all flesh. Until then, we'll just need to acquiesce to an occasional puerile abandon like vaporizing a few ants with a magnifying glass or rendering a holocaust or an influenza epidemic. Until then, well all just have to learn to live with all that lack of healing.


http://www.kidneydoctor.us/types-of-kidney-disease/
Acute Kidney Failure
Acute Phosphate Nephropathy
Acute Tubular Necrosis
Adenovirus Nephritis
Alport Syndrome
Amyloidosis
ANCA Vasculitis related to Endocarditis and other Infections
Angiomyolipoma
Analgesic Nephropathy
Antiphospholipid Syndrome
APOL1 Mutations
Bartter Syndrome
C1q Nephropathy
Cholesterol Emboli
Collapsing Glomerulopathy, Collapsing Glomerulopathy Related to CMV
Contrast Nephropathy
Cryoglobuinemia
Diabetes and Diabetic Kidney Disease
Diabetes Insipidus
Edema, Swelling
Fabry’s Disease
Fanconi Syndrome
Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy
Focal Segmental Glomerulosclerosis, Focal Sclerosis, Focal Glomerulosclerosis
Giant Cell (Temporal) Arteritis with Kidney Involvement
Gestational Hypertension
Gitelman Syndrome
Glomerular Diseases
Goodpasture Syndrome
Hematuria (Blood in Urine)
Hemolytic Uremic Syndrome (HUS), Atypical Hemolytic Uremic Syndrome (aHUS)
Hemosiderosis related to Paroxysmal Nocturnal Hemoglobinuria and Hemolytic Anemia
High Blood Pressure and Kidney Disease
Horseshoe Kidney (Renal Fusion)
Hyperaldosteronism
Hypercalcemia (High Blood Calcium)
Hyponatremia (Low Blood Sodium)
Hyperoxaluria
IgA Nephropathy
IgG4 Nephropathy
Interstitial Cystitis, Painful Bladder Syndrome (Questionnaire)
Interstitial Nephritis
Kidney Stones
Light Chain Deposition Disease, Monoclonal Immunoglobulin Deposition Disease
Liddle Syndrome
Loin Pain Hematuria
Lupus, Systemic Lupus Erythematosis
Lupus Kidney Disease, Lupus Nephritis
Malignant Hypertension
Medullary Cystic Kidney Disease
Medullary Sponge Kidney
Membranoproliferative Glomerulonephritis
Membranous Nephropathy
Metabolic Acidosis
Microscopic Polyangiitis
Minimal Change Disease
Multiple Myeloma
Nail-patella Syndrome
Nephrocalcinosis
Nephrotic Syndrome
Nutcracker syndrome
Orthostatic Hypotension
Orthostatic Proteinuria
Post-infectious Glomerulonephritis, Post-streptococcal Glomerulonephritis
Polycystic Kidney Disease
Preeclampsia
Proteinuria (Protein in Urine)
Pyelonephritis (Kidney Infection)
Rapidly Progressive Glomerulonephritis
Renal Artery Stenosis
Renal Cell Cancer
Renal Infarction
Renal Tubular Acidosis
Renin Secreting Tumors (Juxtaglomerular Cell Tumor)
Reflux Nephropathy
Retroperitoneal Fibrosis
Rhabdomyolysis, Rhabdomyolysis related to Bariatric Sugery
Sarcoidosis
Scleroderma Renal Crisis
Thin Basement Membrane Disease, Benign Familial Hematuria
Tuberous Sclerosis
Tumor Lysis Syndrome
Ureterocele
Urinary Tract Infection
Urinary Tract Obstruction
Von Hippel-Lindau Disease
Warfarin-Related Nephropathy
Wegener’s Granulomatosis, Granumatosis with Polyangiitis

jewish philosopher said...

My car has broken down a few times. I guess that proves that evolution made my car, not an intelligent designer!!

Dave said...

Ahem
God is supposed to be perfect.
Men aren't

jewish philosopher said...

Suffering is a great kindness.

http://www.torahphilosophy.com/2009/08/kindness-of-suffering.html

Of course atheists, having the emotional maturity of spoiled small children, can't accept that.

natschuster said...

Abe:

If the Torah said that Hashem was bad, then there would be no problem. So the problem of suffering doesn't contradict Hashem's existance. It only seems to contradict conventional theology. But theologians have been dealing with these issues for millenia.

Dave:

Perfection has to include the ability to be imperfect. IF Hashem couldn't make something imperfect if He choice to, then He wouldn't be perfect.

Dave said...

If one starts with the assumption that there is a God, and you try to explain everything afterwards, then you can say this kind of apparent absurdity-- like suffering and bad is actually good, and imperfection is part of perfection.

But if you start with the question, "does a biblical god exist?", and then you evaluate the option, based on how logical or reasonable the implications are, you come to a different conclusion.

jewish philosopher said...

One has to weigh the pros and cons and look at the preponderance of evidence, and I have.

http://www.torahphilosophy.com/2012/01/why-weshould-beorthodox.html

There is a ton of evidence against the Holocaust as well.

http://www.holohoax101.com/

A Holocaust denier could argue as well:

If one starts with the assumption that there was a Holocaust, and you try to explain everything afterwards, then you can believe this kind of apparent absurdity-- like that the most civilized and advanced nation on earth maniacally murdered millions of unarmed civilians.

But if you start with the question, "did the Holocaust happen?", and then you evaluate the option, based on how logical or reasonable the implications are, you come to a different conclusion.

Everything comes down to personal judgement and I'm sure that most people reading this understand that Holocaust deniers have a previous bias against Jews which leads them to their conclusions, not a clearheaded evaluation of the evidence. Likewise, Orthodox Jews see clearly that a previous bias against Judaism, for example based on immaturity, irresponsibility, a desire for sexual freedom, leads atheists to their conclusions, not the evidence.

Dave said...

"Everything comes down to personal judgement"

I didn't realize you were such a subjectivist :-)

jewish philosopher said...

People with poor judgement will of course suffer consequences.

natschuster said...

Dave:

If you start by looking at the empirical evidence, then we have to conclude there is a transendent Creator. There is also considerable empirical evidence that He is what humans consider good. Why else did he created humans with the capacity to enjoy sunsets? He communicated to humans via the Torah some of His attributes, If the Torah said He was Bad, there would be no problem. And how do humans know what is good or bad, anyway? How do humans know good or bad even exists? Without G-d, all we have are our very subjective opinions about good and bad. We have to come on to theology to even argue about good or bad.

And Godel proved that every system of logic is contradictory. And Quantum Physics is full of contradictions. And math teaches us that negative numbers don't have square roots. But the square root of negative one keeps on popping up. That's another contradiction. So contradictions aren't a problem in logic, math or physics, so they shouldn't be a problem for theology,

Joe said...

Why doesn't your links work? like:
http://www.torahphilosophy.com/2012/01/why-weshould-beorthodox.html

jewish philosopher said...

I think it works.

Abe said...

"My car has broken down a few times. I guess that proves that evolution made my car, not an intelligent designer!!"

No it proves that you regard your old 1985 Dodge Dart as the equal of god's pretended perfection.
If I ever develop Hemolytic Uremic Syndrome I think it would be better if I were to petition the regenerative therapies of your old clunker. It couldn't do much worse and at least I'm certain that your old clunker exists. Surely that's a vote in favor of the clunker rather than your phantasmal god.

Joe said...

Sorry this one does work. I meant a different one:
http://www.torahphilosophy.com/2009/08/kindness-of-suffering.html

jewish philosopher said...

"No it proves that you regard your old 1985 Dodge Dart as the equal of god's pretended perfection."

Even if a machine is imperfect, as the human body sometimes is due to our many sins, that does not contradict the fact that someone built it.

"I meant a different one"

I think it works.

Dave said...

"Even if a machine is imperfect, as the human body sometimes is due to our many sins, that does not contradict the fact that someone built it."

OK, but when faced with two possible "designers" of a very flawed product: 1. Evolution-imperfect, impersonal, without values; or 2. God-- perfect, all knowing, compassionate, unlimited and all powerful.

The first choice is much more reasonable, IMO.

jewish philosopher said...

I consider myself to be a perfect parent (well, pretty close) yet I still do things which upset my kids - like making them go to bed at 9:00 pm and not serving ice cream three meals a day.

What atheists think is imperfect in God is actually merely immaturity in themselves.

Besides that, evolution couldn't create anything and, based on the fossil record, never happened as I explain.

http://www.torahphilosophy.com/2008/03/evolution-science-hijacked-by-atheism.html

Joe said...

Dave.

If you drive even the most perfect car over a cliff it will get smashed.

Likewise when you sin, it's like jumping off a cliff, even you have the perfect body you will get crushed.

Dave said...

"What atheists think is imperfect in God is actually merely immaturity in themselves."

Not wanting your children to get sick and die is "immaturity"?

Not wanting a plague to wipe out your city is "immaturity"?

It is atheists who are more mature than theists, since they don't have to invent a fantasy of a man in the sky who is taking care of everything.

jewish philosopher said...

"Not wanting your children to get sick and die is "immaturity"?"

I think refusing to accept that you are responsible for your decisions and that your actions have consequences is immature.

"a fantasy of a man in the sky who is taking care of everything."

It makes more sense than the magic evolution fairy.

Dave said...

"I think refusing to accept that you are responsible for your decisions and that your actions have consequences is immature."

I don't think that believers and atheists differ in that. Plenty of non-believers' activity is directly precisely at improving the world by actions under our control.

The difference lies in what consequences we think result from our actions.

We don't believe that children dying of cancer or a plague is consequence of sin, but rather human error/negligence or the inherent randomness in nature.

So we both know that "bad" things happen. In the case of a natural or accidental cause I believe that it results from the same forces that cause a penny to sometimes land tails and sometimes heads.

You believe its because of their or their parent's lack of religiosity.

I believe in probability as a law of nature. Nobody has shown me anything to think otherwise, such as that tragedy strikes pious people any less than anybody else.

You don't.

Its really very simple.

jewish philosopher said...

According to atheism, first of all people have no free will and therefore no moral responsibility. My brain chemistry made me do it.

Secondly, without God, everything is permitted. If it feels good, you are a fool not to do it provided that you can evade law enforcement, which is pretty easy with a little luck and half a brain.

According to Judaism, we do have free will and therefore someone who does evil things is an evil person.

Second of all, according to Judaism, punishment for evil is inevitable sooner or later, in this world, in the next world, in a future life, whenever.

This idea makes atheists, like little children being disciplined by their parents, rant and rave about how God is a psychopathic bully.